Artificial Pancreas Based on Model Predictive Control

Diabetes is recognized as a group of heterogeneous disorders with the common elements of high blood glucose concentration and glucose intolerance, due to insulin deficiency and impaired effectiveness of insulin action. The most common types of diabetes are diabetes mellitus type 1 and diabetes mellitus type 2, which does not necessarily require insulin injections. Type 2 constitutes about 85 to 95% of the approximately 246 million people worldwide with diabetes. The number of type 1 diabetics is estimated to be 10 to 20 million worldwide. Type 1 diabetes occurs when these beta cells are destroyed by the body's own immune system. So, the model is to be developed to recover from diabetes by means of MPC controller. This constrained robust control strategy is developed to reduce risks of hypoand hyperglycemias (low and high blood glucose concentration). Here the role of controller is to regulate the blood glucose level by giving insulin. Closed-loop performance is evaluated through simulation studies of different controllers and it becomes human friendly.